Global Protein Structure Issues
  1. How are 3D macromolecular structures obtained? Crystallography, NMR, and homology modeling.

  2. What fraction of the human proteome has known tertiary structure? A few percent.

  3. Is Structural Genomics the answer? Not in the next few years.

  4. Intrinsicially unstructured proteins:
      About 10% of proteins are thought to be fully disordered to support their functions, and 40% of eukaryotic proteins have at least one long disordered region. Examples.

by Eric Martz, University of Massachusetts, July 2003